Drug Standards
Apexbio Technology LLC Carteolol HCl 51781-21-6 100mg
Carteolol hydrochloride (CAS 51781-21-6) is a non-selective -adrenergic receptor antagonist with partial agonist properties In vitro studies demonstrate that carteolol interacts with 1-adrenergic receptors exhibiting agonist activity at low-affinity (Propranolol-insensitive) sites and antagonistic effects at high-affinity sites In vivo carteolol and its metabolite 8-hydroxy carteolol reduce experimentally induced intraocular pressure (IOP) in animal models with the metabolite showing enhanced efficacy Carteolol is widely utilized in research relating to cardiovascular diseases and ocular hypertension including the modeling of chronic glaucoma and -adrenergic signaling pathways
Medchemexpress LLC Ethyl gallate | 831-61-8 | 198.17 | 1 G
Ethyl gallate is a nonflavonoid phenolic compound that acts as a scavenger of hydrogen peroxide. It exhibits cytotoxic effects on HL-60 cells, inducing apoptosis, decreasing cell viability in a time- and dose-dependent manner, and increasing cells in the subG1 phase. It also modulates protein expression by decreasing Bcl-2 and increasing Bax and truncated Bid (tBid).
- Nonflavonoid phenolic compound
- Scavenges hydrogen peroxide
- Induces apoptosis in HL-60 cells
- Decreases cell viability in a time- and dose-dependent manner
- Increases proportion of cells in subG1 phase
- Modulates protein expression by decreasing Bcl-2 and increasing Bax and truncated Bid (tBid)
Medchemexpress LLC Benzoic acid, 2-methoxy-5-methyl-, methyl ester | 63113-79-1 | MFCD06411343 | 10g
Ilurodoline impurity 10 is an impurity of Ilurodoline
Medchemexpress LLC Anastrozole impurity 10 | 120511-74-2 | MFCD07782113 | 1g
Anastrozole impurity 10 is an impurity of Anastrozole (HY-14274)
Apexbio Technology LLC Triamcinolone 124-94-7 10mM (in 1mL DMSO)
Triamcinolone (124-94-7) is a small-molecule agonist targeting intracellular glucocorticoid receptors (GR) It is designed to modulate the transcriptional regulation of genes involved in inflammation immune responses cellular proliferation vascular permeability and angiogenesis thereby regulating multiple cellular and immunological pathways Triamcinolone exerts its biological activity primarily through binding to GR and modulating downstream gene expression In cell-based GR assays Triamcinolone demonstrates potent receptor binding with reported IC50 values typically ranging from 0 5 to 5 nM Based on these pharmacological properties Triamcinolone holds research potential in experimental models of dermatological inflammation ophthalmic inflammation autoimmune conditions and investigations of GR-mediated signal transduction and immunoregulatory pathways
Sigma Aldrich Fine Chemicals Biosciences Bacampicillin hydrochloride European Pharmacopoeia (EP) Reference Standard | 37661-08-8 |
Bacampicillin hydrochloride European Pharmacopoeia (EP) Reference Standard | Mol Wt: 501.98 | 37661-08-8 |
Sigma Aldrich Fine Chemicals Biosciences Oxaliplatin System Suitability United States Pharmacopeia (USP) Reference Standard | 61848-66-6 | 25MG
Oxaliplatin System Suitability United States Pharmacopeia (USP) Reference Standard | Mol Wt: 380.17 | 61848-66-6 | 25MG
Sigma Aldrich Fine Chemicals Biosciences Cromolyn Related Compound B United States Pharmacopeia (USP) Reference Standard | 16150-45-1 | 25MG
Cromolyn Related Compound B United States Pharmacopeia (USP) Reference Standard | Mol Wt: 524.47 | 16150-45-1 | 25MG
Sigma Aldrich Fine Chemicals Biosciences Bumetanide Related Compound B United States Pharmacopeia (USP) Reference Standard | 28328-53-2 | 25MG
Bumetanide Related Compound B United States Pharmacopeia (USP) Reference Standard | Mol Wt: 338.29 | 28328-53-2 | 25MG
Medchemexpress LLC Rosuvastatin (Calcium) | 147098-20-2 | 99.8% | 500.57 | 1 ML
Rosuvastatin Calcium is a competitive HMG-CoA reductase (HMGCR) inhibitor that potently blocks hERG current. It effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.
- Competitive HMG-CoA reductase (HMGCR) inhibitor.
- Potently blocks hERG current.
- Reduces expression of mature hERG and interaction with heat shock protein 70 (Hsp70).
- Effectively lowers LDL cholesterol, triglycerides, and C-reactive protein levels.
Medchemexpress LLC Latanoprost | 130209-82-4 | MFCD00864319 | >98% | 25 MG
Latanoprost is a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor. It is primarily used in glaucoma research to effectively reduce intraocular pressure (IOP) by increasing the outflow of aqueous humor through the uvea. It can effectively pass through the cornea and is hydrolyzed by esterase to latanoprost acid.
- Prostaglandin F2α analogue
- Agonist for the FP prostanoid receptor
- Lowers intraocular pressure (IOP)
- Inhibits VEGF-induced proliferation and migration in human umbilical vein endothelial cells (HUVECs)
- Suppresses retinal neovascularization in vitro
- Increases cell viability in HUVECs and human retinal microvascular endothelial cells (HRMECs)
- Decreases levels of Akt, Erk1/2, NF-κB, and VEGF expression
- Reduces blood flow in the optic nerve head, iris, and choroid
- Inhibits the development of choroidal neovascularization in mice
Medchemexpress LLC Etoricoxib impurity 17 | 307531-95-9 | 25mg
Etoricoxib impurity 17 is an impurity of Etoricoxib (HY-15321)
![eMolecules 2243507-51-7 | Ambeed | rel-(3aS7aS)-(5-Methyloctahydro-7aH-pyrrolo[34-c]pyridin-7a-yl)methanol dihydrochloride | 25mg | 672838188 | A1492717 | 486.34 | C18H40Cl4N4O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502448081.PNG-250.jpg)
eMolecules 2243507-51-7 | Ambeed | rel-(3aS7aS)-(5-Methyloctahydro-7aH-pyrrolo[34-c]pyridin-7a-yl)methanol dihydrochloride | 25mg | 672838188 | A1492717 | 486.34 | C18H40Cl4N4O2
ChemScene | 2-Chloro-4-isopropylphenol | 100mg | 632308025 | CS-0162893 | 51202-00-7 | MFCD16997172 | 170.640 | C9H11ClO
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Medchemexpress LLC Cabozantinib (Standard) | 849217-68-1 | 99.3% | 100 MG
Cabozantinib (Standard) is the analytical standard of Cabozantinib, intended for research and analytical applications. It is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035 nM and 1.3 nM, respectively. This compound also demonstrates strong inhibition of KIT, RET, AXL, TIE2, and FLT3. Cabozantinib exhibits antiangiogenic activity and disrupts tumor vasculature, promoting tumor and endothelial cell apoptosis.
- Serves as a reference standard for assays
- Commonly used in qualitative, quantitative, and methodological research experiments
- Suitable for techniques such as HPLC, GC, and MS
- Potent and orally active inhibitor of VEGFR2 and MET
- Strongly inhibits KIT, RET, AXL, TIE2, and FLT3
- Exhibits antiangiogenic activity
- Disrupts tumor vasculature
- Promotes tumor and endothelial cell apoptosis
Selleck Chemical LLC Gandotinib (LY2784544) 5mg 1229236-86-5
Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.